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Research - Journal of Veterinary Pharmacology

Research - Journal of Veterinary PharmacologyAs reported in the Journal of Veterinary Pharmacology and Therapeutics:

In a clinical study of obese-arthritic dogs undertaken to evaluate clinical efficacy and safety of undenatured type-II collagen (UC-II) after 90 days the animals taking daily doses of UC-II showed significant declines in overall pain and pain during limb manipulation and lameness after physical exertion.

Lameness and pain were measured on a weekly basis and blood samples were assayed for creatinine and blood urea nitrogen (markers of renal injury); and alanine aminotransferase and aspartate aminotransferase (evidence of hepatic injury).

In addition, dogs receiving UC-II for 90 days showed increased physical activity level. Following withdrawal for a period of 30 days, all dogs experienced a relapse of overall pain, exercise-associated lameness, and pain upon limb manipulation.

These results suggest that daily treatment of arthritic dogs with UC-II ameliorates signs and symptoms of arthritis, and UC-II is well tolerated as no adverse effects were noted.

In large breed dogs, arthritis is very common because of obesity, injury, aging, immune disorder, or genetic predispositions. This study was therefore undertaken to evaluate clinical efficacy and safety of undenatured type-II collagen (UC-II) in obese-arthritic dogs.

These results suggest that daily treatment of arthritic dogs with UC-II ameliorates signs and symptoms of arthritis, and UC-II is well tolerated as no adverse effects were noted.



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Research - Journal of Veterinary Pharmacology